Multimodal Imaging: Elements & Molecules in Biological Samples
Catia Costa & Melanie J. Bailey

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Catia Costa, et al. Analytical Chemistry 2025 97 (30), 16573-16582

DOI: 10.1021/acs.analchem.5c02890

Secondary ion mass spectrometry (SIMS) and particle induced X-ray emission (PIXE)

☐  Sequential molecular and elemental mapping using water cluster SIMS and PIXE.

☐  Developed a workflow that can be applied to biological
     tissues/cells for
multimodal elemental and molecular imaging at            the micron scale using keV and MeV ion beams on the same sample
☐  This work opens up the exciting prospect of colocalizing metals or       other elements with metabolites and lipids in biological systems             below the single cell level, and future work will need to explore             how  to deal with the difference in information depths