Ion Beam Analysis of Metals in Proteins
Geoffrey W. Grime

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Pounot, Kevin et al. Biophysical Journal, 120, Issue 5, 886 – 898
DOI:  10.1016/j.bpj.2020.11.2280

Examples
Human Insulin: The importance of Zinc (Zn)

Diabetics who inject insulin may suffer from amyloidosis, an inflammation at the injection site.

  • Caused by insulin aggregating to form fibrils and spherulites that compromise its action.
  • PIXE showed that zinc is expelled on aggregation of insulin.

 

  • PIXE was crucial for the study and this finding is helping develop treatments for amyloidosis.