Multimodal Imaging: Elements & Molecules in Biological Samples
Catia Costa & Melanie J. Bailey
Why multimodal imaging?

We are developing analytical strategies to combine MeV ion beam elemental mapping with mass spectrometry imaging (MSI).

This will help to understand (e.g.) the impact of…

☐  Metal nanoparticles
☐  Elemental accumulation/depletion
☐  Metal containing drugs
… on the local chemistry (e.g. metabolites, proteins, lipids).

But…

… we want to perform sequential measurements on a single sample, because features are not always accurately reproduced in sequential sections.

What are the challenges?

☐  Expertise and   instrumentation are not               normally co-located
☐  Different sample handling requirements
☐  Techniques are potentially destructive                 (what is the correct workflow?)
☐  Different data handling strategies